Central Valley, California, is home to some of the most impoverished rural
towns in America, where crystal meth addiction is prolific. In Fresno, Louis Theroux finds a community ravaged by this cheap and highly addictive drug. As he infiltrates the town, he experiences the reality of meth abuse, as addicts who are high (or 'tweaking', as it is known) invite him into their homes to see them take hit after hit of their favourite drug. Louis becomes surrounded by the madness of daily addiction and the meth-addled confusion which is breaking this community apart.
