This is the story of how history made science and how science made history, and how the ideas which emerged made the modern world. It is a tale of courage and of fear, of hope and disaster, of persistence and success. It interweaves great forces of history revolutions, voyages of discovery and artistic movements with practical, ingenious inventions and the dogged determination of experimenters and scientists. For thousands of years we have wrestled with the great questions of existence. Who are we? What is the world made of? How did we get here? The quest to answer these is the story of science.